Covid-19: Novel Coronavirus Content Free to Access
Following an outbreak of pneumonia without a clear cause in the city of Wuhan in China, a novel strain of coronavirus (2019-nCoV) was detected in December 2019.
Coronaviruses were identified in the mid-1960s and are known to infect humans and a variety of animals (including birds and mammals). Since 2002, two coronaviruses infecting animals have evolved and caused outbreaks in humans: SARS-CoV (Severe Acute Respiratory Syndrome) identified in southern China in 2003, and and MERS-CoV (Middle East Respiratory Syndrome), identified in Saudi Arabia in 2012. Together, they have caused more than 1600 deaths.
It’s in these times of crisis where communities come together even more. As a publisher of trusted health science, we’ve made the relevant research articles, book chapters and entries in our major references freely available below, in support of the global efforts in diagnosis, treatment, prevention and further research in this disease and similar viral respiratory infections. Our approach is to use the world-class information we have available to directly improve health and to support the virtual efforts of healthcare practitioners globally. We are continually monitoring the developments and we will update the content of this page periodically.
Dr Charles Young
Editor in Chief
International Journal of Clinical Practice
In addition to the articles below related to the current outbreak, Wiley is also making a collection of journal articles and our book chapters on coronavirus research freely available to the global scientific community. On workdays, newly published articles are made free within 24 hours of publication. Articles published after 14:00 (EST) on Friday will be made free the following Monday.
Novel Coronavirus Outbreak
December 2019 to present
free access
Development of epitope‐based peptide vaccine against novel Coronavirus 2019 (SARS‐COV‐2): Immunoinformatics approach
- Manojit Bhattacharya
- Ashish Ranjan Sharma
- Prasanta Patra
- Pratik Ghosh
- Garima Sharma
- Bidhan Chandra Patra
- Sang‐Soo Lee
- Chiranjib Chakraborty
free access
COVID‐19: Lessons from SARS and MERS
free access
Development and Clinical Application of A Rapid IgM‐IgG Combined Antibody Test for SARS‐CoV‐2 Infection Diagnosis
- Zhengtu Li
- Yongxiang Yi
- Xiaomei Luo
- Nian Xiong
- Yang Liu
- Shaoqiang Li
- Ruilin Sun
- Yanqun Wang
- Bicheng Hu
- Wei Chen
- Yongchen Zhang
- Jing Wang
- Baofu Huang
- Ye Lin
- Jiasheng Yang
- Wensheng Cai
- Xuefeng Wang
- Jing Cheng
- Zhiqiang Chen
- Kangjun Sun
- Weimin Pan
- Zhifei Zhan
- Liyan Chen
- Feng Ye
free access
Evolutionary history, potential intermediate animal host, and cross‐species analyses of SARS‐CoV‐2
free access
Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS‐CoV‐2 infection
free access
Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2
- Zhixin Liu
- Xiao Xiao
- Xiuli Wei
- Jian Li
- Jing Yang
- Huabing Tan
- Jianyong Zhu
- Qiwei Zhang
- Jianguo Wu
- Long Liu
free access
‘It's a virus, Jim, but not as we know it…’
free access
Clinical characteristics of 140 patients infected with SARS‐CoV‐2 in Wuhan, China
- Jin-jin Zhang
- Xiang Dong
- Yi-yuan Cao
- Ya-dong Yuan
- Yi-bin Yang
- You-qin Yan
- Cezmi A. Akdis
- Ya-dong Gao
free access
Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak — United States, December 31, 2019–February 4, 2020
Abstract
This article summarizes what is currently known about the 2019 novel coronavirus and offers interim guidance.
free access
Coronavirus Disease 2019: Implications of Emerging Infections for Transplantation
- Marian G Michaels
- Ricardo M. La Hoz
- Lara Danziger Isakov
- Emily A. Blumberg
- Deepali Kumar
- Michael Green
- Timothy L. Pruett
- Cameron R. Wolfe
Open access
Novel coronavirus 2019 (COVID‐19): Emergence and implications for emergency care
- Jane Yee MD
- Lucy Unger MD
- Frank Zadravecz MD
- Paloma Cariello MD
- Allan Seibert MD
- Michael Austin Johnson MD, PhD
- Matthew Joseph Fuller MD
free access
COVID‐2019: The role of the nsp2 and nsp3 in its pathogenesis
- Silvia Angeletti
- Domenico Benvenuto
- Martina Bianchi
- Marta Giovanetti
- Stefano Pascarella
- Massimo Ciccozzi
free access
The course of clinical diagnosis and treatment of a case infected with coronavirus disease 2019
- Wenzheng Han
- Bin Quan
- Yi Guo
- Jun Zhang
- Yong Lu
- Gang Feng
- Qiwen Wu
- Fang Fang
- Long Cheng
- Nanlin Jiao
- Xiaoning Li
- Qing Chen
free access
The COVID‐19 epidemic
Open access
2019_nCoV/SARS‐CoV‐2: rapid classification of betacoronaviruses and identification of Traditional Chinese Medicine as potential origin of zoonotic coronaviruses
Abstract
Significance and Impact of the Study: The noncoding upstream and downstream flanks of coronavirus genomes allow for rapid classification of novel Betacoronavirus species and correct identification of genetic relationships. Although bats are the likely natural host of 2019_nCoV, the exact bat species that serves as the natural host of the virus remains as yet unknown. Chinese bat species with commercial value were identified as natural reservoirs of coronaviruses and are used in Traditional Chinese Medicine. Since their trading provides a potential risk for spreading zoonoses, a change in these practices is highly recommended.
free access
Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS‐CoV, MERS‐CoV, and 2019‐nCoV
- Jia Liu
- Xin Zheng
- Qiaoxia Tong
- Wei Li
- Baoju Wang
- Kathrin Sutter
- Mirko Trilling
- Mengji Lu
- Ulf Dittmer
- Dongliang Yang
free access
Preliminary prediction of the basic reproduction number of the Wuhan novel coronavirus 2019‐nCoV
free access
Public responses to the novel 2019 coronavirus (2019‐nCoV) in Japan: Mental health consequences and target populations
free access
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019‐nCoV
Abstract
What′s sauce for the goose? Little is known about the coronavirus causing the current outbreak; however, it shares strong sequence homology with its better‐studied cousin SARS‐CoV. Based on previous studies of targeting SARS‐CoV, we suggest four potential candidates that could be used to drug the viral spike protein, RNA‐dependent RNA polymerase, and coronavirus main proteinase.
free access
Updated understanding of the outbreak of 2019 novel coronavirus (2019‐nCoV) in Wuhan, China
free access
The 2019‐new coronavirus epidemic: Evidence for virus evolution
- Domenico Benvenuto
- Marta Giovanetti
- Alessandra Ciccozzi
- Silvia Spoto
- Silvia Angeletti
- Massimo Ciccozzi
Understanding Coronavirus
free access
Gold nanoparticle‐adjuvanted S protein induces a strong antigen‐specific IgG response against severe acute respiratory syndrome‐related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs
- Hanako Sekimukai
- Naoko Iwata‐Yoshikawa
- Shuetsu Fukushi
- Hideki Tani
- Michiyo Kataoka
- Tadaki Suzuki
- Hideki Hasegawa
- Kenichi Niikura
- Katsuhiko Arai
- Noriyo Nagata
free access
Amotosalen and ultraviolet A light efficiently inactivate MERS‐coronavirus in human platelet concentrates
- A. M. Hashem
- A. M. Hassan
- A. M. Tolah
- M. A. Alsaadi
- Q. Abunada
- G. A. Damanhouri
- S. A. El‐Kafrawy
- M. Picard‐Maureau
- E. I. Azhar
- S. I. Hindawi
free access
A Case Study Evaluating the Risk of Infection from Middle Eastern Respiratory Syndrome Coronavirus (MERS‐CoV) in a Hospital Setting Through Bioaerosols
- Umesh Adhikari
- Alexandre Chabrelie
- Mark Weir
- Kevin Boehnke
- Erica McKenzie
- Luisa Ikner
- Meng Wang
- Qing Wang
- Kyana Young
- Charles N. Haas
- Joan Rose
- Jade Mitchell
- Risk Analysis
- 2608-2624
- 10.1111/risa.13389
free access
Severe acute respiratory syndrome coronavirus spike protein counteracts BST2‐mediated restriction of virus‐like particle release
- Journal of Medical Virology
- 1743-1750
- 10.1002/jmv.25518
free access
Viromimetic STING Agonist‐Loaded Hollow Polymeric Nanoparticles for Safe and Effective Vaccination against Middle East Respiratory Syndrome Coronavirus
- Leon Chien‐Wei Lin
- Chen‐Yu Huang
- Bing‐Yu Yao
- Jung‐Chen Lin
- Anurodh Agrawal
- Abdullah Algaissi
- Bi‐Hung Peng
- Yu‐Han Liu
- Ping‐Han Huang
- Rong‐Huay Juang
- Yuan‐Chih Chang
- Chien‐Te Tseng
- Hui‐Wen Chen
- Che‐Ming Jack Hu
Abstract
To improve vaccination efforts against Middle East respiratory syndrome coronavirus (MERS‐CoV), a virus‐mimicking vaccine is herein prepared with a capsid‐like hollow polymeric nanoparticle loaded with STING agonists and coated in MERS‐CoV antigens. The viromimetic nanoparticle facilitates safe and effective vaccination against the lethal virus and offers a versatile platform for combatting emerging infectious threats.
free access
Development of a diagnostic system for detection of specific antibodies and antigens against Middle East respiratory syndrome coronavirus
- Kunse Lee
- Hae Li Ko
- Eun‐Young Lee
- Hyo‐Jung Park
- Young Seok Kim
- Yeon‐Sook Kim
- Nam‐Hyuk Cho
- Man‐Seong Park
- Sang‐Myeong Lee
- Jihye Kim
- Hun Kim
- Baik Lin Seong
- Jae‐Hwan Nam
free access
Proficiency testing for the detection of Middle East respiratory syndrome coronavirus demonstrates global capacity to detect Middle East respiratory syndrome coronavirus
- Torsten Theis
- Katherine A. Lau
- Joanna L. Gray
- Christopher J. Oxenford
- Gregory J. Walker
- William D. Rawlinson
- Journal of Medical Virology
- 1827-1833
- 10.1002/jmv.25266
free access
Update: Severe Respiratory Illness Associated With a Novel Coronavirus—Worldwide, 2012–2013
Abstract
A novel coronavirus associated with severe respiratory tract illness and person‐to‐person spread has been described in patients with travel to the Arabian peninsula and neighboring countries as well as their close contacts. Although not yet described in transplant recipients or donors, providers should be aware of this association.
Epidemiology and prevention
free access
Bat‐borne viruses in Africa: a critical review
Abstract
Hundreds of viruses have been described from bats in Africa, some with proven spillover and causing human deaths, however for the majority there is no information on spillover potential. We summarize and critically analyze the current knowledge on African bats as reservoirs for corona, filo, paramyxo and lyssaviruses, including important characteristics of bats like biology, evolution, distribution and ecology that not only make them unique amongst most mammals but also contribute to their potential as viral reservoirs. We highlight the gaps in knowledge that is often not available to make informed decisions on zoonotic spillover potential. Despite this it is still important to recognize the role of bats in zoonotic disease outbreaks and implement mitigation strategies to prevent exposure to infectious agents, including working safely with bats. Equally important is the crucial role of bats in various ecosystem services.
free access
Evaluating the ALERT algorithm for local outbreak onset detection in seasonal infectious disease surveillance data
- Alexandria C. Brown
- Stephen A. Lauer
- Christine C. Robinson
- Ann‐Christine Nyquist
- Suchitra Rao
- Nicholas G. Reich
free access
Molecular viral epidemiology and clinical characterization of acute febrile respiratory infections in hospitalized children in Taiwan
- Journal of Medical Virology
- 1860-1866
- 10.1002/jmv.24258
Drug discovery and therapy
free access
Computational modeling of the bat HKU4 coronavirus 3CLpro inhibitors as a tool for the development of antivirals against the emerging Middle East respiratory syndrome (MERS) coronavirus
Abstract
3CLpro has been proposed as a potential target for the treatment of MERS‐CoV infection. The bat HKU4‐CoV 3CLpro has been exploited as a model for MERS‐CoV 3CLpro (81% sequence identity). We explored the pharmacophoric space of a set of peptidomimetic inhibitors of HKU4‐CoV 3CLpro. The established pharmacophores highlight structural features needed for ligand recognition and were used as 3D queries to screen the NCI database for novel nonpeptidomimetic 3CLpro inhibitors. The identified hits were tested for HKU4‐CoV and MERS‐CoV 3CLpro inhibition.
free access
Synthesis and anti‐coronavirus activity of a series of 1‐thia‐4‐azaspiro[4.5]decan‐3‐one derivatives
Abstract
A new series of thiazolidinones were designed, synthesized, and evaluated for antiviral activity. Seven compounds exhibited favorable inhibitory effects on human coronavirus 229E virus replication. 8n was the most potent analog having an EC50 value of 5.5 µM.
Book Chapters and Encyclopedic Entries
Free Access
Spray Drying – CHAPTER 7
Drying Technologies for Biotechnology and Pharmaceutical Applications (Pages: 179-216)
Free Access
Viral Infections and Global Change – CHAPTER 6
HUMAN BEHAVIOR AND THE EPIDEMIOLOGY OF VIRAL ZOONOSES (Pages: 87-109)
Free Access
Principles and Practice of Clinical Virology – CHAPTER 3
Viral Transmission: Infection Acquired by All Other Routes (Respiratory, Eye–Nose–Mouth, Inoculation and Faeco‐Orally) (Pages: 43-68)
Wiley Encyclopedia of Molecular Medicine
Coronavirus
Free Access
Biological Safety – CHAPTER 9
Viral Agents of Human Disease: Biosafety Concerns (Pages: 187-220)
Free Access
Diagnostic Microbiology of the Immunocompromised Host – CHAPTER 11
Respiratory RNA Viruses (Pages: 233-271)
Free Access
Manual of Commercial Methods in Clinical Microbiology – CHAPTER 6
Molecular Tests for the Identification of Viruses (Pages: 97-120)
eLS
Coronaviruses
