Covid-19: Novel Coronavirus Outbreak

Although most patients recover within several weeks after acute COVID-19, some of them develop chronic injury of different organs or have nonspecific long-lasting clinical symptoms. Renal transplant recipients have clinical and laboratory complications after acute COVID-19.

Low dose whole lung irradiation could improve the chest X-ray severity score and oxygen saturation in severely ill COVID-19 patients, but larger studies are required to determine its impact on mortality.

The online survey showed that individuals with bipolar disorder (BD) reported overall poor sleep in comparison with healthy controls during total lockdown due to the COVID-19 pandemic as well as when restrictions were loosened. Individuals with BD informed themselves more frequently about pandemic-related topics and higher information frequency and more COVID-19 fears (about the virus, own infection, contracting others) correlated with worse sleep. Regression models found in BD group that higher information frequency as well as higher COVID-19 fears in April predicted worse sleep characteristics in May, in particular subjective sleep quality, sleep duration, sleep efficiency, and daytime sleepiness.

Raman spectroscopy has been used to diagnose COVID-19 in serum samples of subjects without clinical symptoms of COVID-19. The main spectral differences between the positive IgM and IgG versus Control were features assigned to proteins, lipids (including phospholipids), immunoglobulins, carotenoids, nucleic acids, and amino acids (tryptophan). Discriminant model applied to the Raman spectra could discriminate positive Ig groups versus Control with an accuracy of 90.3%. Raman spectroscopy may become a technique for rapid serological evaluation aiming diagnosis of COVID-19 infection.

We describe a series of 16 cases of COVID-related tardive pseudoperniosis (PP). Symptoms in all patients persisted beyond 2 months. Positive autoimmune serological markers and an arachnodactyloid phenotype were observed in some patients and may represent risk factors. Underlying connective tissue disorders, anorexia or sickle cell trait may also predispose to prolonged PP.

The global pandemic of the coronavirus disease 2019 represents a major concern for health services worldwide, also inducing major changes in cytopathology practice.

We retrospectively analyzed data from 6537 predominantly hospitalized COVID-19 patients registered in the European multinational Lean European Open Survey on SARS-Infected Patients (LEOSS) registry between January 2020 and February 2021. Common neurological symptoms were excessive tiredness (28.0%), headache (18.5%), nausea/emesis (16.6%), muscular weakness (17.0%), impaired sense of smell (9.0%) and taste (12.8%), and delirium (6.7%). Most frequent neurological complications were ischemic stroke (1.0%) and intracerebral bleeding (2.2%) in patients with a complicated or critical disease course. Excessive tiredness (odds ratio [OR] 1.42) and prior neurodegenerative disease (OR 1.32) were associated with an increased risk of an unfavorable outcome.

The authors attempt to increase the solubility of testosterone and progesterone via interaction with ionic liquids. An increase in the value of dipole moment is observed for the complex of testosterone/progesterone and the ionic liquids in comparison of individual one based on DFT calculations. Testosterone-IL1 {IL1-3-(2-hydroxyethyl)-1-methyl-1H-imidazol-3-ium 2,4,6-trinitrophenolate} is found to be prominent against main protease of SARS-CoV-2.

The effect of the coronavirus (COVID-19) pandemic was assessed on food safety knowledge, hygiene practices, and eating attitudes of academics and university students in Turkey. Gender was the most prominent factor associated with 9 out of 10 hygiene practices before and during the coronavirus pandemic. This study indicates that reactions of both academics and university students are similar during the coronavirus pandemic for food safety-associated knowledge, practices, and attitudes.

We use a meta-analysis to explore the correlation between cardiac-related comorbidities, cardiac biomarkers, acute myocardial injury, and severity level, outcomes in patients with COVID-19. Most of the findings clearly indicate that hypertension, cardiovascular disease, acute cardiac injury, and related laboratory indicators are associated with the severity of COVID-19. What is now needed are cross-national prospectively designed observational or clinical trials that will help improve the certainty of the available evidence and treatment decision for patients.

We report here that 18% of severe COVID-19 patients were positive for autoantibodies able to neutralize type I interferon (IFN). This finding further confirms the deleterious role of IFN-I auto-Abs in the antiviral immune response supporting the use of recombinant type I IFNs not targeted by the auto-Abs (e.g. IFN-β) in COVID-19 patients with an impairment of the IFN-I response.

With an aim to rationalize mutation‘s impact on virus biology, in this review, we explore the literature on key spike mutations of harbored by these SARS-CoV-2 Variant of Concerns (VOCs). Focus of the article has been on portraying the molecular picture of critical spike mutations of four SARS-CoV-2 lineages (B.1.1.7, B.1.351, P.1 and B.1.617.2) in simplified manner and correlates it with the observed biological response.

The COVID-19 pandemic has had widespread societal changes, resulting in a substantial decrease in trauma presentations. Despite COVID's immense impact on the Royal Melbourne Hospital's level 1 trauma service, the quality of care was not compromised.