Covid-19: Novel Coronavirus Outbreak

Rapid diagnostics are essential for early detection of COVID-19 and reduced disease spread. In this study, we discovered the DNA aptamer SNAP1 (SARS-CoV-2 spike protein N-terminal domain binding aptamer 1), which binds with high affinity and specificity to SARS-CoV-2 spike protein as well as UV-inactivated SARS-CoV-2 virus.

All criticisms expressed by Tyshkovskiy and Panchin (10.1002/bies.202000325) on our paper (10.1002/bies.202000240) are either incorrect, as built on the false premise that we have suggested RaTG13 to be a direct progenitor of SARS-CoV-2, or irrelevant to our analysis. SARS-CoV-2's genetic structure remains consistent with both natural and man-made origin.

COVID-19 infection is well known for inducing severe proriasis flares in patients with well-documented disease. Herein, we report the case of new-onset guttate psoriasis following COVID-19 infection.

Various strategies are used to endow four important functions in masks, including: i) anti-microbial and self-disinfectant characteristics by metal nanoparticles or photosensitizers, ii) self-cleaning properties by inserting superhydrophobic materials such as graphenes and silanes, iii) photo/electrothermal properties by forming graphene and metal thin films, and iv) incorporating triboelectric nanogenerators to stabilize the electrostatic charges and facilitate the recharging of masks.

Nanotechnology-mediated RNA delivery enables regulating a broad range of cellular processes providing effective strategies for personalized medicine. This review provides a comprehensive overview of the recent evidence in the field, highlighting key RNA molecules and nanostructured carriers. Their innovative applications for vaccine development, wound healing, cancer, and neural system treatments are summarized. Finally, new trends and future applications are discussed.

During COVID-19, WRRFs faced several challenges, including technical, operational, maintenance, and personnel management related issues. These challenges interrupted facilities' overall performance in many different ways. Thus, adopting and learning emergency resources plan and smart operations can help facilities to mitigate challenges during pandemic and other interruptions.

• The epiMOX dashboard (https://www.epimox.polimi.it) enables data analysis of the COVID-19 epidemic in Italy from late February 2020.
• epiMOX fosters immediate appreciation of the past and current epidemic trends through critical indicators.
• epiMOX predicts near future epidemic evolution based on an epidemiological compartmental model named SUIHTER.

We followed up COVID-19 patients discharged from the hospital up to 7 months post infection. We found that the neutralizing antibody responses are declining while T-cell immunities are sustained in COVID-19 patients during the follow-up.

SARS-CoV-2 vaccines are amenable to immunogenetic response prediction. The same challenge (virus, vaccine) could provoke complete, partial, or failed protection and variable reactogenicity among individuals. We review genetic variation in immunity and HLA. Production platforms (mRNA, vectors, and proteins) may elicit genetically distinct reactogenic profiles. Vaccine recipient bioprofiling advances personalized health.