Novel Coronavirus Outbreak Oct 9 - Oct 16

Most recent articles (newest articles listed first)

Open access

Intravenous immunoglobulin immunotherapy for coronavirus disease‐19 (COVID‐19)

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Intravenous immunoglobulin (IVIG), a pooled normal IgG from several thousand healthy donors and one of the commonly used immunotherapeutic molecules for the management of autoimmune and inflammatory diseases, has been explored for the treatment of coronavirus disease-19 (COVID-19). Although placebo-controlled, double-blind randomised clinical trials are lacking, current data from either retrospective, case series or open-label randomised controlled trials provide an indicator that IVIG immunotherapy could benefit severe and critically ill COVID-19 patients. See alsoShao et al.

Open access

Management of pulmonary contusions during the COVID‐19 pandemic

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Repeat reverse transcription–polymerase chain reaction testing and follow-up computed tomography are useful for differentiating between COVID-19 and pulmonary contusions.

Open access

CHARACTERISTICS and considerations in the medical treatment of COVID‐19 in children

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We summarized the characteristics of coronavirus disease 2019 (COVID-19) in children and the important points in pediatric emergency care during the COVID-19 pandemic based on literature and epidemiological data published as of June 10, 2020. Health-care providers are required to examine the children’s circumstances carefully and cooperate with workers in other professions appropriately.

Open access

A Hydrophobic‐Interaction‐Based Mechanism Triggers Docking between the SARS‐CoV‐2 Spike and Angiotensin‐Converting Enzyme 2

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Understanding the mechanism responsible for the outstanding affinity between the novel severe acute respiratory syndrome coronavirus 2 spike (SARS-CoV-2 S) and human angiotensin-converting enzyme 2 (ACE2) is an “urgent challenge” for developing blockers, vaccines, and therapeutic antibodies against the coronavirus disease (COVID-19) pandemic. Taking into account the mechanisms of hydrophobic effects and the shielding effects of water molecules, a hydrophobic-interaction-based mechanism by means of which SARS-CoV-2 S and ACE2 bind together in an aqueous environment is revealed.

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Slower recovery of outpatient clinics than inpatient services for stroke and other neurological diseases after COVID‐19 Pandemic

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The changes in outpatient visits and inpatient services from the neurology department in a tertiary hospital in Shanghai, China, where there was no official city lockdown during the pandemic. A. It indicates the clinic visits from January 2019 to July 2020. Clinic visits dropped by 36.6% in February 2020 as compared to that in February in 2019, with a partial rebound as the effects of the pandemic waned; B. It indicates the inpatient services in stroke and all neurological diseases from January 2019 to July 2020. Inpatient services in stroke and all neurological diseases dropped by 27.4% and 23.8%, respectively, in February 2020 as compared to that in February in 2019 and then rose rapidly to a nearly normal status

Open access

Clinical efficacy of intravenous immunoglobulin therapy in critical ill patients with COVID‐19: a multicenter retrospective cohort study

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Early administration of a high dose of intravenous immunoglobulin (IVIG) improves the prognosis of critical-type patients with COVID-19. This study provides important information on clinical application of IVIG in the treatment of SARS-CoV-2 infection, including patient selection and administration dosage and timing.

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The clinical characteristics and prognosis of COVID‐19 patients with cerebral stroke: A retrospective study of 113 cases from one single‐centre

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Of the 2,474 COVID-19 patients in the Tongji Hospital, 113 (4.7%) patients had cerebral stroke, and 25 (1.0%) patients had new-onset stroke. In 113 (4.7%) stroke patients, 88 (77.9%) patients in the previous-stroke, while 25 (22.1%) patients in the new-onset. Most COVID-19 patients with stroke were elderly with more comorbidities such as hypertension, diabetes and heart diseases. Laboratory examinations showed hypercoagulation and elevated serum parameters such as IL-6, cTnI. The mortality rate of stroke patients was almost double that of patients without stroke. In conclusion, COVID-19 patients with an elderly age combined with a history of hypertension were more likely happening new-onset stroke. These patients are more vulnerable to multiorgan dysfunction and an overactivated inflammatory response, in turn leading to a higher mortality rate.

Open access

Targeted Nanotherapeutics for Respiratory Diseases: Cancer, Fibrosis, and Coronavirus

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Targeted delivery of nanotherapeutics specifically to diseased lungs, pulmonary cells, and/or specific organelles offers distinct advantages over systemic delivery by enhancing efficacy of the treatment and limiting severe adverse side effects. Nanoscale based systems can transport various types of payload, simultaneously carry out several distinct tasks and perform multiple function in diagnosis, treatment, and suppression of cellular resistance.

Open access

Tocilizumab for treating severe COVID‐19 pneumonia refractory to combined hydroxychloroquine, lopinavir plus ritonavir, and favipiravir: A case series

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Tocilizumab could be used in patients with severe COVID-19 pneumonia who did not show response to a combination of antiviral therapy. However, the use of a combination antiviral therapy should be further confirmed in clinical trials.

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Syncytia formation by SARS‐CoV‐2‐infected cells

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Cells infected with SARS-CoV-2 can fuse with neighbouring cells in a process accelerated by infectivity-enhancing host factor TMPRSS2 and restricted by antiviral IFITM proteins.

Open access

Association between HLA gene polymorphisms and mortality of COVID‐19: An in silico analysis

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We conducted in silico analyses and examined an association of HLA gene polymorphisms with prevalence and mortality of COVID-19 by using publicly available databases. We found that the association between HLA-A*02:01 and increased risk for COVID-19 is probably due to the lower capacity of the genotype to present SARS-CoV-2 antigens. Our study suggests that identifying the HLA genotype associated with the severity of COVID-19 or susceptibility to SARS-CoV-2 may support future vaccination strategies to genotypically at-risk populations.

Open access

Repositioning microbial biotechnology against COVID‐19: the case of microbial production of flavonoids

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Coronavirus-related disease 2019 (COVID-19) became a pandemic in February 2020 and worldwide researchers try to tackle the disease with approved drugs of all kinds, or to develop novel compounds inhibiting viral spreading. Flavonoids, already investigated as antivirals in general, also might bear activities specific for the viral agent causing COVID-19, SARS-CoV-2. Microbial biotechnology and especially synthetic biology may help to produce novel flavonoids with antiviral activity.

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Impact of COVID-19-related social restrictions on orthopaedic trauma in a level 1 trauma centre in Sydney: the first wave

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This study examines the impact that social distancing measures introduced to combat coronavirus disease 2019 (COVID-19) have had on the orthopaedic trauma load at a level 1 trauma hospital in Sydney.

Open access

Teaching during a pandemic: Using high‐impact writing assignments to balance rigor, engagement, flexibility, and workload

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Writing-intensive courses may be one of the easiest high-impact educational practices for science faculty to adopt as they adjust to teaching during the pandemic. Writing assignments promote lasting conceptual learning, deepen student engagement, offer flexible implementation, and can be designed to reduce the possibility of cheating and plagiarism. To accelerate the adoption of writing pedagogies, we summarize characteristics of effective writing assignments, offer a sample writing assignment from an introductory ecology course, and suggest strategies to help instructors manage their workload.

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Impact of Covid19 on electricity load in Haryana (India)

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In prevailing situations of Covid19, the energy consumption in India plummeted dramatically due to full or partial lockdown measures imposed by the government. In this work electricity load forecasting for state Haryana (India) is done for a week so as to know the required electricity load pre-hand which will aid the regional power systems to plan accordingly and avoid unnecessary power wastage.